Background. A prominent nasolabial fold (NLF) is a cosmetic problem. Currently, numerous therapeutic modalities are available\nfor pronounced NLFs with variable efficacy. Objective. To determine the efficacy and safety of subcision using a hypodermic needle\nfor the correction of the prominent NLFs and its effect on skin elasticity. Methods. Sixteen patients with prominent NLFs underwent\nsubcision. The investigators� assessment of improvement and the patients� satisfaction were both recorded 1 and 6 months after the\nprocedure. Also,we evaluate the skin elasticity of NLFs before and after the treatment using a sensitive biometrologic device with the\nmeasurement of cutaneous resonance running time (CRRT). Results. Thirteen (81.25%) patients showed a moderate improvement\nat 1st month and 13 (81.25%) patients had at least amild improvement at 6th month. There was no persistent side effect lastingmore\nthan a few days. Mean CRRT at 1 and 6 months after the treatment was significantly higher compared to the baseline. Conclusion.\nSubcision may be considered effective for the correction of pronounced NLFs. However, further controlled studies with larger\nsample size are necessary to assess the efficacy of this technique in particularwith use of more objective assessment of skin biometric\ncharacteristics. This trial is registered with IRCT201108097270N1 (registered on January 27, 2012).
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